Greenville Christian School was formulated in the minds of concerned Christian parents from Christ Wesleyan Methodist Church. The school opened in late August, 1969, at the the Greenville Hotel with thirty-seven students in grades one through nine.

In 1972, the new facility at Highway 1 south was completed, and the fall class began. The school grew rapidly, and increased enrollment necessitated additional classrooms. 

In 1979, the school was recognized under the governing body of the Greenville Christian School Parents' Association.

Since 1983, four new classrooms have been added, an athletic/training building has been constructed and a large science complex has been completed.

The school is accredited by the Southern Association of Colleges and Schools and the Mississippi Private School Asscociation.

Greenville Christian School admits students of any race, color, national or ethnic origin to all the rights, privileges, programs, and activities generally accorded or made available to students at the school. It does not discriminate on the basis of race, color, national or ethnic origin in administration of its educational policies, admissions policies, and athletic and other school administered programs.